HIGHLIGHTED TOPIC Role of Exercise in Reducing the Risk of Diabetes and Obesity PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men
نویسندگان
چکیده
Alejandro Lucia, Félix Gómez-Gallego, Inês Barroso, Manuel Rabadán, Fernando Bandrés, Alejandro F. San Juan, José L. Chicharro, Ulf Ekelund, Soren Brage, Conrad P. Earnest, Nicholas J. Wareham, and Paul W. Franks European University of Madrid, Madrid, Spain; Department of Toxicology, Complutense University, Madrid, Spain; The Wellcome Trust Sanger Institute, Metabolic Disease Group, Cambridge, United Kingdom; Department of Sports Medicine, Higher Sports Council, Madrid, Spain; School of Nursing, Complutense University, Madrid, Spain; Medical Research Center Epidemiology Unit, Cambridge, United Kingdom; The Cooper Institute Center for Human Performance and Nutrition Research, Dallas, Texas; and Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona
منابع مشابه
PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men.
Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PPARGC1A) gene product in the development of maximal oxygen uptake (V(O2 max)), a determinant of endurance capacity, diabetes, and early death. We tested the hypothesis that the frequency of the minor Ser482 allele at the PPARGC1A locus is lower in World-class Spanish male enduranc...
متن کاملThe PPARGC1A Gly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men
BACKGROUND The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction. METHODS The PPARGC1A Gly482Ser polymorphism was genotyped in a community-based cohort of 499 men and 533 women...
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OBJECTIVE A lower frequency for the peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A) Ser482 allele has been reported in elite-level endurance athletes among Caucasians, although this gene polymorphism has not been found to be associated with aerobic capacity in German, Dutch or Chinese populations. The purpose of the current study was to examine the associations between th...
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تاریخ انتشار 2005